Behçet's disease is a disease that destroys blood vessels through systemic inflammation, manifesting as painful oral and genital ulcers, as well as vision destroying inflammation of the eyes. NHGRI researchers from Dan Kastner, M.D. Ph.D.'s group in the Inflammatory Disease Section of the Division of Intramural Research investigated the genetics using Illumina's Immunochip. This genotyping chip can identify the specific single changes in DNA that correlate with autoimmune and inflammatory diseases. They found novel DNA changes that are correlated with disease susceptibility, many of which are involved in immune response to invading pathogens.
Credit: Darryl Leja , NHGRI.